PhytophthoraV1, Main, Exploration, bibRecord, 000678

Random mutagenesis screen shows that Phytophthora capsici CRN83_152-mediated cell death is not required for its virulence function(s).

Identifieur interne : 000678 ( Main/Exploration ); précédent : 000677; suivant : 000679

Random mutagenesis screen shows that Phytophthora capsici CRN83_152-mediated cell death is not required for its virulence function(s).

Auteurs : Tiago M M M. Amaro [Royaume-Uni] ; Gaëtan J A. Thilliez [Royaume-Uni] ; Rory A. Mcleod [Royaume-Uni] ; Edgar Huitema [Royaume-Uni]

Source :

Molecular plant pathology [ 1364-3703 ] ; 2018.

RBID : pubmed:28779542

Descripteurs français

KwdFr :
- Chromatine (métabolisme), Dépistage génétique (MeSH), Mort cellulaire (MeSH), Mutagenèse (génétique), Phytophthora (génétique), Phytophthora (pathogénicité), Phénotype (MeSH), Protéines (composition chimique), Protéines (génétique), Séquence d'acides aminés (MeSH), Séquence nucléotidique (MeSH), Tabac (cytologie), Tabac (microbiologie), Virulence (MeSH).
MESH :
- composition chimique : Protéines.
- cytologie : Tabac.
- génétique : Mutagenèse, Phytophthora, Protéines.
- microbiologie : Tabac.
- métabolisme : Chromatine.
- pathogénicité : Phytophthora.
- Dépistage génétique, Mort cellulaire, Phénotype, Séquence d'acides aminés, Séquence nucléotidique, Virulence.

English descriptors

KwdEn :
- Amino Acid Sequence (MeSH), Base Sequence (MeSH), Cell Death (MeSH), Chromatin (metabolism), Genetic Testing (MeSH), Mutagenesis (genetics), Phenotype (MeSH), Phytophthora (genetics), Phytophthora (pathogenicity), Proteins (chemistry), Proteins (genetics), Tobacco (cytology), Tobacco (microbiology), Virulence (MeSH).
MESH :
- chemical , chemistry : Proteins.
- chemical , genetics : Proteins.
- chemical , metabolism : Chromatin.
- cytology : Tobacco.
- genetics : Mutagenesis, Phytophthora.
- microbiology : Tobacco.
- pathogenicity : Phytophthora.
- Amino Acid Sequence, Base Sequence, Cell Death, Genetic Testing, Phenotype, Virulence.

Abstract

With the increasing availability of plant pathogen genomes, secreted proteins that aid infection (effectors) have emerged as key factors that help to govern plant-microbe interactions. The conserved CRN (CRinkling and Necrosis) effector family was first described in oomycetes by their capacity to induce host cell death. Despite recent advances towards the elucidation of CRN virulence functions, the relevance of CRN-induced cell death remains unclear. In planta over-expression of PcCRN83_152, a CRN effector from Phytophthora capsici, causes host cell death and boosts P. capsici virulence. We used these features to ask whether PcCRN83_152-induced cell death is linked to its virulence function. By randomly mutating this effector, we generated PcCRN83_152 variants with no cell death (NCD) phenotypes, which were subsequently tested for activity towards enhanced virulence. We showed that a subset of PcCRN83_152 NCD variants retained their ability to boost P. capsici virulence. Moreover, NCD variants were shown to have a suppressive effect on PcCRN83_152-mediated cell death. Our work shows that PcCRN83_152-induced cell death and virulence function can be separated. Moreover, if these findings hold true for other cell death-inducing CRN effectors, this work, in turn, will provide a framework for studies aimed at unveiling the virulence functions of these effectors.

DOI: 10.1111/mpp.12590
PubMed: 28779542
PubMed Central: PMC5947615

Affiliations:

Royaume-Uni

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000926
to stream Main, to step Curation: 000926

Le document en format XML

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<term>Chromatin (metabolism)</term>
<term>Genetic Testing (MeSH)</term>
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<term>Phytophthora (pathogenicity)</term>
<term>Proteins (chemistry)</term>
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<term>Phytophthora (pathogénicité)</term>
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<front><div type="abstract" xml:lang="en">With the increasing availability of plant pathogen genomes, secreted proteins that aid infection (effectors) have emerged as key factors that help to govern plant-microbe interactions. The conserved CRN (CRinkling and Necrosis) effector family was first described in oomycetes by their capacity to induce host cell death. Despite recent advances towards the elucidation of CRN virulence functions, the relevance of CRN-induced cell death remains unclear. In planta over-expression of PcCRN83_152, a CRN effector from Phytophthora capsici, causes host cell death and boosts P. capsici virulence. We used these features to ask whether PcCRN83_152-induced cell death is linked to its virulence function. By randomly mutating this effector, we generated PcCRN83_152 variants with no cell death (NCD) phenotypes, which were subsequently tested for activity towards enhanced virulence. We showed that a subset of PcCRN83_152 NCD variants retained their ability to boost P. capsici virulence. Moreover, NCD variants were shown to have a suppressive effect on PcCRN83_152-mediated cell death. Our work shows that PcCRN83_152-induced cell death and virulence function can be separated. Moreover, if these findings hold true for other cell death-inducing CRN effectors, this work, in turn, will provide a framework for studies aimed at unveiling the virulence functions of these effectors.</div>
</front>
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<Abstract><AbstractText>With the increasing availability of plant pathogen genomes, secreted proteins that aid infection (effectors) have emerged as key factors that help to govern plant-microbe interactions. The conserved CRN (CRinkling and Necrosis) effector family was first described in oomycetes by their capacity to induce host cell death. Despite recent advances towards the elucidation of CRN virulence functions, the relevance of CRN-induced cell death remains unclear. In planta over-expression of PcCRN83_152, a CRN effector from Phytophthora capsici, causes host cell death and boosts P. capsici virulence. We used these features to ask whether PcCRN83_152-induced cell death is linked to its virulence function. By randomly mutating this effector, we generated PcCRN83_152 variants with no cell death (NCD) phenotypes, which were subsequently tested for activity towards enhanced virulence. We showed that a subset of PcCRN83_152 NCD variants retained their ability to boost P. capsici virulence. Moreover, NCD variants were shown to have a suppressive effect on PcCRN83_152-mediated cell death. Our work shows that PcCRN83_152-induced cell death and virulence function can be separated. Moreover, if these findings hold true for other cell death-inducing CRN effectors, this work, in turn, will provide a framework for studies aimed at unveiling the virulence functions of these effectors.</AbstractText>
<CopyrightInformation>© 2017 THE AUTHORS. MOLECULAR PLANT PATHOLOGY PUBLISHED BY BRITISH SOCIETY FOR PLANT PATHOLOGY AND JOHN WILEY & SONS LTD.</CopyrightInformation>
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<AffiliationInfo><Affiliation>Cell and Molecular Sciences, JHI, Invergowrie, Dundee DD2 5DA, UK.</Affiliation>
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	Serveur d'exploration Phytophthora
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Random mutagenesis screen shows that Phytophthora capsici CRN83_152-mediated cell death is not required for its virulence function(s).

Random mutagenesis screen shows that Phytophthora capsici CRN83_152-mediated cell death is not required for its virulence function(s).

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